Phenotype Standardization for Immune-Mediated Drug-Induced Skin Injury
Identifieur interne : 006836 ( Main/Exploration ); précédent : 006835; suivant : 006837Phenotype Standardization for Immune-Mediated Drug-Induced Skin Injury
Auteurs : M. Pirmohamed [Royaume-Uni] ; P. S. Friedmann [Royaume-Uni] ; M. Molokhia [Royaume-Uni] ; Y. K. Loke [Royaume-Uni] ; C. Smith [Royaume-Uni] ; E. Phillips [Australie] ; L. La Grenade [États-Unis] ; B. Carleton [Canada] ; M. Papaluca-Amati [Royaume-Uni] ; P. Demoly [France] ; N. H. Shear [Canada]Source :
- Clinical pharmacology and therapeutics [ 0009-9236 ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Normalisation, Médicament, Homme.
English descriptors
- KwdEn :
Abstract
Advances in genetic research and molecular biology techniques have made it possible to begin to characterize the underlying genetic factors that predispose patients to serious forms of drug-induced skin injury (DISI).To facilitate research in this area, we have set out standardized phenotypic definitions for (i) Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), (ii) acute generalized exanthematous pustulosis (AGEP), and (iii) hypersensitivity syndrome (HSS; also known as drug reaction with eosinophilia and systemic symptoms (DRESS) and drug-induced hypersensitivity syndrome (DIHS)). A DISI Expert Working Group comprising participants with varied expertise reviewed and debated current terminology and diagnostic criteria for DISI and agreed on the minimum phenotypic criteria for selected forms of DISI (SJS/ TEN, AGEP, and HSS). In addition, an algorithm has been developed to aid appropriate clinical categorization of patients with DISI.These standardized criteria will be important in facilitating adequate and accurate patient recruitment in order to advance research in pharmacogenomic, immunological, mechanistic, and epidemiological studies.
Affiliations:
- Australie, Canada, France, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Languedoc-Roussillon, Maryland, Occitanie (région administrative), Ontario
- Londres, Montpellier, Toronto
- Université de Toronto
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Le document en format XML
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<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>European Medicines Agency</s1>
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<author><name sortKey="Demoly, P" sort="Demoly, P" uniqKey="Demoly P" first="P." last="Demoly">P. Demoly</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Drug</term>
<term>Human</term>
<term>Immune system</term>
<term>Phenotype</term>
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<term>Standardization</term>
<term>Toxicity</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Phénotype</term>
<term>Normalisation</term>
<term>Système immunitaire</term>
<term>Médicament</term>
<term>Toxicité</term>
<term>Peau</term>
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<front><div type="abstract" xml:lang="en">Advances in genetic research and molecular biology techniques have made it possible to begin to characterize the underlying genetic factors that predispose patients to serious forms of drug-induced skin injury (DISI).To facilitate research in this area, we have set out standardized phenotypic definitions for (i) Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), (ii) acute generalized exanthematous pustulosis (AGEP), and (iii) hypersensitivity syndrome (HSS; also known as drug reaction with eosinophilia and systemic symptoms (DRESS) and drug-induced hypersensitivity syndrome (DIHS)). A DISI Expert Working Group comprising participants with varied expertise reviewed and debated current terminology and diagnostic criteria for DISI and agreed on the minimum phenotypic criteria for selected forms of DISI (SJS/ TEN, AGEP, and HSS). In addition, an algorithm has been developed to aid appropriate clinical categorization of patients with DISI.These standardized criteria will be important in facilitating adequate and accurate patient recruitment in order to advance research in pharmacogenomic, immunological, mechanistic, and epidemiological studies.</div>
</front>
</TEI>
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<li>Canada</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
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<li>Maryland</li>
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<name sortKey="Papaluca Amati, M" sort="Papaluca Amati, M" uniqKey="Papaluca Amati M" first="M." last="Papaluca-Amati">M. Papaluca-Amati</name>
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<country name="États-Unis"><region name="Maryland"><name sortKey="La Grenade, L" sort="La Grenade, L" uniqKey="La Grenade L" first="L." last="La Grenade">L. La Grenade</name>
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<country name="France"><region name="Occitanie (région administrative)"><name sortKey="Demoly, P" sort="Demoly, P" uniqKey="Demoly P" first="P." last="Demoly">P. Demoly</name>
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